> I will try to do some prototyping around that to see how much can we gain in that route. In any case, adding LOAD_METHOD support for all kinds of calls should be an improvement by itself even without caching, no?

Exactly.

As one argument for generalizing of LOAD_METHOD is that I, for example, try not to use kwargs in hot paths because I know it will be slower, which feels very wrong. I shouldn't care of internal implementation details of CPython and focus on writing readable code.