Due to the European achievement in the 1963–64 season, Inter also debuted in the Intercontinental Cup facing off with Independiente. After two legs, the aggregate score resulted in a draw; the cup was awarded by a tie-breaker, in which Inter won 1–0 at extra time.

In Serie A Inter suffered a 3–0 loss in the Derby della Madonnina.^[1] In late January, there were two draws in row and an uprising defeat, by Foggia in matchday 19.^[1] So, in the middle of the season, AC Milan had 7 points over Inter with 15 games to play.^[1] The following months saw a historical comeback from the side, that won 13 times and drew twice: 28 points were earned this way, resulting in first place.^[1] Mazzola had a central role in team play, scoring 17 goals to be the league's top-scorer.^[1]

On May 27, a year on exactly from the previous win, Inter retained the European title by beating Benfica at the San Siro: Jair was the scorer.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.

Pos. Nation Player GK  ITA Ottavio Bugatti GK  ITA Rosario Di Vincenzo GK  ITA Giuliano Sarti DF  ITA Tarcisio Burgnich DF  ITA Giorgio Dellagiovanna DF  ITA Giacinto Facchetti DF  ITA Aristide Guarneri DF  ITA Spartaco Landini DF  ITA Armando Picchi MF  ITA Gianfranco Bedin MF  ITA Mario Corso MF  ITA Sergio Gori

Pos. Nation Player MF  ITA Saul Malatrasi MF  ITA Sandro Mazzola MF  ESP Luis Suárez MF  ITA Carlo Tagnin MF  ITA Franco Zaglio FW  ITA Francesco Canella FW  BRA Jair FW  ITA Angelo Domenghini FW  ITA Aurelio Milani FW  ESP Joaquín Peiró FW  ITA Bruno Petroni

• History of Grande Inter