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Chemical compound
Pharmaceutical compound
6-Fluoro-AMT
Clinical data
Other names6-Fluoro-AMT; 6-Fluoro-αMT; 6F-AMT; 6F-αMT; 6-F-AMT; 6-F-αMT; 6-Fluoro-α-methyltryptamine
Routes of
administration		Oral
Drug classSerotonergic psychedelic; Hallucinogen
Identifiers
  • 1-(6-fluoro-1H-indol-3-yl)propan-2-amine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC11H13FN2
Molar mass192.237 g·mol−1
3D model (JSmol)
  • NC(C)CC1=CNC2=CC(F)=CC=C21
  • InChI=1S/C11H13FN2/c1-7(13)4-8-6-14-11-5-9(12)2-3-10(8)11/h2-3,5-7,14H,4,13H2,1H3
  • Key:XYJYWUUXCUJXAI-UHFFFAOYSA-N

6-Fluoro-AMT, or 6-fluoro-αMT, also known as 6-fluoro-α-methyltryptamine, is a psychedelic drug of the tryptamine family related to α-methyltryptamine (AMT) and 5-MeO-AMT.[1][2]

Use and effects

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6-Fluoro-AMT was allegedly manufactured and sold from the laboratory operated by Leonard Pickard and Gordon Todd Skinner, who described 6-fluoro-AMT as "a beast".[1] In interviews, Skinner stated that he first began to experiment with 6-fluoro-AMT in the early 1980s by giving it to high school friends.[2] Their experiences made him cautious about the appropriate doses, which he said ranged from 25 to 75 mg (Skinner weighed about 250 lbs at the time of his own bioassay).[2] Skinner said that 6-fluoro-AMT is a long-lasting psychedelic with more time distortion and that it was enhanced by combination with ALD-52.[2]

Interactions

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Pharmacology

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Pharmacodynamics

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Animal tests showed the drug to be somewhat less potent in terms of pharmacological activity than AMT or 5-fluoro-AMT.[3] It produces the head-twitch response, a behavioral proxy of psychedelic-like effects, in rodents.[5] Its IC50Tooltip half-maximal inhibitory concentration for monoamine oxidase A (MAO-A) inhibition is 580 to 1,800 nM, compared to 180 to 450 nM for 5-fluoro-AMT and 380 nM for AMT.[5][7][8]

Chemistry

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Analogues

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Analogues of 6-fluoro-AMT include α-methyltryptamine (AMT), 5-fluoro-AMT, 5-chloro-AMT, 5-fluoro-AET, 5-chloro-AET, 6-fluoro-DMT, 6-fluoro-DET, 6-methyl-DMT, 6-MeO-DMT, 6-hydroxy-DMT, 7-chloro-AMT, and O-4310 (1-isopropyl-6-fluoro-4-HO-DMT), among others.

History

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6-Fluoro-AMT was first described in the scientific literature, by Asher Kalir and Stephen Szara, by at least 1963.[3]

Society and culture

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6-Fluoro-AMT is not an explicitly nor implicitly controlled substance in Canada as of 2025.[9]

United States

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6-Fluoro-AMT is not an explicitly controlled substance in the United States.[10] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

See also

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References

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  1. 1 2 Morris H (2010). "Life is a Cosmic Giggle on the Breath of the Universe. A Tour of Gordon Todd Skinner's Subterranean LSD Palace". Vice Magazine. Archived from the original on 2014-10-13. Retrieved 2017-08-23.
  2. 1 2 3 4 "Unusual Analogues: Drugs Used by Gordon Todd Skinner". thislandpress.com. This Land Press. Archived from the original on 17 April 2016. Retrieved 8 April 2016.
  3. 1 2 Kalir A, Szara S (November 1963). "Synthesis and Pharmacological Activity of Fluorinated Tryptamine Derivatives". Journal of Medicinal Chemistry. 6 (6): 716–719. doi:10.1021/jm00342a019. PMID 14184932.
  4. 1 2 Nakagawasai O, Arai Y, Satoh SE, Satoh N, Neda M, Hozumi M, Oka R, Hiraga H, Tadano T (January 2004). "Monoamine oxidase and head-twitch response in mice. Mechanisms of alpha-methylated substrate derivatives". Neurotoxicology. 25 (1–2): 223–232. Bibcode:2004NeuTx..25..223N. doi:10.1016/S0161-813X(03)00101-3. PMID 14697897.
  5. ↑ Wagmann L, Brandt SD, Kavanagh PV, Maurer HH, Meyer MR (April 2017). "In vitro monoamine oxidase inhibition potential of alpha-methyltryptamine analog new psychoactive substances for assessing possible toxic risks" (PDF). Toxicol Lett. 272: 84–93. doi:10.1016/j.toxlet.2017.03.007. PMID 28302559.
  6. ↑ WO 2022061242, Matthew Baggott, "Advantageous tryptamine compositions for mental disorders or enhancement", published 2023 March 24, assigned to Tactogen 
  7. ↑ "Controlled Drugs and Substances Act". Department of Justice Canada. 5 December 2025. Retrieved 20 January 2026.
  8. ↑ Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) (PDF), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026
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