| Heck's disease | |
|---|---|
| Other names | Focal epithelial hyperplasia, multifocal epithelial hyperplasia |
 | |
| Specialty | Oral and maxillofacial surgery  |
Heck's disease, also known as focal (or multifocal) epithelial hyperplasia, is an asymptomatic, benign neoplastic condition characterized by multiple white to pinkish papules that occur diffusely in the mouth.[1][2]: 411 It can present with slightly pale, smooth or roughened surface morphology. It is caused by the human papilloma virus types 13 and 32.[3] It exhibits surface cells with vacuolated cytoplasm around irregular, pyknotic nuclei and occasional cells with mitosis-like changes within otherwise mature and well-differentiated epithelium. A distinguishing histologic feature is elongated rete ridges with mitosoid bodies. It shows "cobblestone" appearance clinically. It was first identified among young Native American patients in the 1960s.[4]
Over time, the papules will spontaneously regress without treatment.[5] Possible treatment may be excisional biopsy for lesions of functional or aesthetic concern.[citation needed]
References
[edit]- ↑
- ↑ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
- ↑ James, William D.; Berger, Timothy; Elston, Dirk (2015). Andrews' Diseases of the Skin E-book: Clinical Dermatology. Elsevier Health Sciences. p. 408. ISBN 9780323319690.
- ↑ Archard, Howell O.; Heck, John W.; Stanley, Harold R. (1965). "Focal epithelial hyperplasia: An unusual oral mucosal lesion found in Indian children". Oral Surgery, Oral Medicine, Oral Pathology. 20 (2): 201–212. doi:10.1016/0030-4220(65)90192-1. PMID 14322615.
- ↑ Eversole, Lewis R. (2011). Clinical Outline of Oral Pathology: Diagnosis and Treatment. PMPH-USA. p. 285. ISBN 9781607950158. Retrieved 18 January 2018.