• Jurnee Smollett as Letitia "Leti" Lewis, an old friend and love interest of Atticus, who is a skilled photographer^[6]
• Jonathan Majors as Atticus "Tic" Freeman, a young man who served in the Korean War. Majors also portrays George Freeman II, Tic's future son, in photographs.^[6]
• Aunjanue Ellis as Hippolyta Freeman, Atticus's aunt and a star-gazer with an itch for adventure^[6]
• Courtney B. Vance as George Freeman, Atticus's warm, funny and well-read uncle.^[6] Vance also portrays another George from an alternate timeline in "I Am.".^[6]
• Wunmi Mosaku as Ruby Baptiste, Leti's estranged older half-sister.^[6] Mosaku also portrays Christina Braithwhite having taken Ruby's form.^[6]
• Abbey Lee as Christina Braithwhite, the sole daughter of the leader of the secret society known as the Order of the Ancient Dawn^[6]
• Jamie Chung as Ji-Ah, a seemingly naïve Korean nursing student whom Atticus had an affair with. She is also possessed by a kumiho.
• Jada Harris as Diana Freeman, George and Hippolyta's daughter as well as Atticus's younger cousin and Montrose's niece^[6]
• Michael K. Williams as Montrose Freeman, Atticus's hard-headed and secretive father^[6]

• Jordan Patrick Smith as William, Christina's former henchman and lover, whose form she assumes
• Joaquina Kalukango as Hanna, Atticus's slave ancestor, a former cleaning woman in Titus Braithwhite's mansion
• Jamie Neumann as Dell / Hillary, whose form Ruby assumes
• Erica Tazel as Dora Freeman, Atticus's mother, Montrose's wife and George's lover / sister-in-law
• Mac Brandt as Seamus Lancaster, an Order of the Ancient Dawn leader and Chicago police captain
• Deron J. Powell as Tree, a man who attended high school with Leti and Atticus
• Lucius Baston as Phil Hodges, the locksmith
• Regina Taylor as Hattie
• Rhyan Hill as Emmett "Bobo" Till
• Sibongile Mlambo as Tamara
• Jonathan Pawlowski as Burke

• Jamie Harris as Eustice Hunt, the sheriff of Devon County
• Demetrius Grosse as Marvin Baptiste, Leti's half-brother
• Tony Goldwyn as Samuel Braithwhite, the arrogant leader of a secret society
• Shangela as Lena Horne
• Monét X Change as Dinah Washington
• Darryl Stephens as Billie Holiday
• James Kyson as Byung-Ho
• Monique Candelaria as Yahima, two-spirit
• Matthew Alan as Deputy Eastchurch
• Michael Rose as Titus Braithwhite

On May 16, 2017, it was announced that HBO had given a series order to Lovecraft Country. Executive producers include Misha Green, Jordan Peele, J. J. Abrams, and Ben Stephenson. Additionally, Green serves as the series' showrunner and wrote the pilot episode. Production companies involved in the series include Monkeypaw Productions, Bad Robot, and Warner Bros. Television. It was reported that Peele originally brought the project to Bad Robot and enlisted Green to develop the show.^{[18][19][20][21]}

On March 5, 2018, it was announced that Yann Demange would direct and executive produce the pilot episode.^[22][23][24]

On April 26, 2018, it was announced that Jurnee Smollett had been cast as the series' female lead.^[25] On May 2, 2018, it was reported that Jonathan Majors had joined the main cast as the series' male lead.^[26] A day later, it was reported that Wunmi Mosaku had also been cast as a series regular.^[27] On June 19, 2018, it was announced that Aunjanue Ellis and Elizabeth Debicki had been cast as series regulars and that Courtney B. Vance had joined the series in a recurring capacity.^[28] On October 10, 2018, it was reported that Michael Kenneth Williams had been cast in a leading role.^[29] On June 14, 2019, it was reported that Abbey Lee had replaced Debicki in the role of Christina Braithwaite, while Jamie Chung and Jordan Patrick Smith had been cast in recurring roles.^[30] On June 20, 2019, it was announced that Jamie Neumann, Erica Tazel, and Mac Brandt had been cast in recurring capacities.^[31] In July 2019, Tony Goldwyn joined the cast.^[32]

Principal photography for the series began on July 16, 2018, in Chicago, Illinois.^[33] Filming also reportedly took place at the Chicago Cinespace Film Studios^[34] in Elburn, Illinois^[35] and White Pines State Park in Mount Morris, Illinois,^[36] at Blackhall Studios in Atlanta, Georgia and Macon, Georgia.^[37]

Laura Karpman composed the music for the show. Due to the COVID-19 pandemic, Karpman and her composing team had to score the show individually from their residences in eastern Europe, with Karpman adding some music tracks of her playing piano, keyboards, and other instruments. Karpman reflected on how difficult it was composing the show with the pandemic's restrictions, due to not being able to have immediate interaction with the musicians. She felt satisfied with the finished result.^[38]

While a second season had yet to be officially greenlit for production, by February 2021, HBO's president of programming Casey Bloys announced that Misha Green had begun writing and was in early planning stages.^[39] On July 2, 2021, HBO announced that the series would not be returning for a second season.^[40] In James Andrew Miller's book Tinderbox: HBO's Ruthless Pursuit of New Frontiers, several writers of the show alleged that the cancellation was due to Green's creation of a hostile work environment.^[41]

The complete series was released on February 16, 2021, on Blu-ray and DVD.^[44]

Lovecraft Country has received positive reviews. On review aggregator website Rotten Tomatoes, the series holds an approval rating of 88% based on 367 reviews, with an average rating of 8.05/10. The site's critics consensus reads: "Anchored by Jurnee Smollett-Bell and Jonathan Majors' heroic performances, Misha Green's Lovecraft Country is a thrilling take on Lovecraftian lore that proves the Elder Gods aren't the only thing that goes bump in the cosmos."^[45] On Metacritic, the series has a weighted average score of 79 out of 100, based on 42 critics, indicating "generally favorable reviews".^[46]

Writing for The A.V. Club, Shannon Miller lauded the show's ability to balance Lovecraft's more problematic political views with "an appreciation for [his] unparalleled vision".^[47] Brian Tallerico of RogerEbert.com pointed to the show's use of genre storytelling "to peel back layers of American history to reveal the systemic problems underneath it", while also describing it as "marvelously entertaining".^[48] Hugo Rifkind of The Times described the show as "brutal and righteously furious".^[49] The Chicago Tribune's Michael Phillips, in reference to earlier, less successful attempts at adaptation of Lovecraft's works, said the show "succeeds where others have not" and commended the show on its themes, despite calling the five episodes available for early review "uneven".^[50] The New York Times's Mike Hale credited Green's "impressively seamless job... in wielding the cultural metaphors" as part of the show's strength.^[51] In a review for The Dispatch, Alec Dent praised the show's success at "examin[ing] racism in America's past through an unexpected genre", calling it a good reminder that "oftentimes true evil takes a normal guise".^[52] In a more critical review, Daniel D'Addario of Variety wrote that "the violence of Lovecraftian horror is so extreme [...] that even the most evil impulses of humanity seem an inadequate counterweight".^[53]

In an analysis of the series, Maya Phillips of The New York Times criticized it for "exploiting [the past] for the purposes of its convoluted fiction", despite a promising premise. She accused the show's creators of using historical events purely "to get points for relevance", notable examples of this being the funeral of Emmett Till and the Tulsa race massacre, both of which are featured in the show.^[1]