MTF1

MTF1
Identifiers
Aliases	MTF1, MTF-1, ZRF, metal-regulatory transcription factor 1, metal regulatory transcription factor 1
External IDs	OMIM: 600172; MGI: 101786; HomoloGene: 4347; GeneCards: MTF1; OMA:MTF1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	37,859,592 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	124,743,593 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; buccal mucosa cell; ; mucosa of paranasal sinus; ; oral cavity; ; epithelium of bronchus; ; bronchial epithelial cell; ; nipple; ; internal globus pallidus; ; tendon of biceps brachii; ; gums;
	Top expressed in
	spermatid; ; zygote; ; spermatocyte; ; seminiferous tubule; ; secondary oocyte; ; primary oocyte; ; internal carotid artery; ; motor neuron; ; lacrimal gland; ; retinal pigment epithelium;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity; transcription coactivator activity; DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding; protein binding; histone acetyltransferase binding; nucleic acid binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding;
Cellular component	nucleus; nucleoplasm;
Biological process	response to cadmium ion; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; response to metal ion; response to oxidative stress; transcription, DNA-templated; positive regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; central nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	4520
	17764
	ENSG00000188786
	ENSMUSG00000028890
	Q14872
	Q07243
	NM_005955
	NM_008636
	NP_005946
	NP_032662
	Wikidata
View/Edit Human	View/Edit Mouse

Protein-coding gene in the species Homo sapiens

Metal regulatory transcription factor 1 is a protein that in humans is encoded by the MTF1 gene.^[5]^[6]

Function

This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000188786 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028890 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑
1 2 "Entrez Gene: MTF1 metal-regulatory transcription factor 1".

Westin G, Schaffner W (Dec 1988). "A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene". The EMBO Journal. 7 (12): 3763–70. doi:10.1002/j.1460-2075.1988.tb03260.x. PMC 454951. PMID 3208749.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Chen X, Chu M, Giedroc DP (Sep 1999). "MRE-Binding transcription factor-1: weak zinc-binding finger domains 5 and 6 modulate the structure, affinity, and specificity of the metal-response element complex". Biochemistry. 38 (39): 12915–25. doi:10.1021/bi9913000. PMID 10504263.
Otsuka F, Okugaito I, Ohsawa M, Iwamatsu A, Suzuki K, Koizumi S (Jul 2000). "Novel responses of ZRF, a variant of human MTF-1, to in vivo treatment with heavy metals". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1492 (2–3): 330–40. doi:10.1016/s0167-4781(00)00110-x. PMID 11004505.
Saydam N, Georgiev O, Nakano MY, Greber UF, Schaffner W (Jul 2001). "Nucleo-cytoplasmic trafficking of metal-regulatory transcription factor 1 is regulated by diverse stress signals". The Journal of Biological Chemistry. 276 (27): 25487–95. doi:10.1074/jbc.M009154200. PMID 11306562.
Majumder S, Ghoshal K, Summers D, Bai S, Datta J, Jacob ST (Jul 2003). "Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1". The Journal of Biological Chemistry. 278 (28): 26216–26. doi:10.1074/jbc.M302887200. PMC 2365495. PMID 12716893.
Saydam N, Steiner F, Georgiev O, Schaffner W (Aug 2003). "Heat and heavy metal stress synergize to mediate transcriptional hyperactivation by metal-responsive transcription factor MTF-1". The Journal of Biological Chemistry. 278 (34): 31879–83. doi:10.1074/jbc.M302138200. PMID 12805380.
Chen X, Zhang B, Harmon PM, Schaffner W, Peterson DO, Giedroc DP (Feb 2004). "A novel cysteine cluster in human metal-responsive transcription factor 1 is required for heavy metal-induced transcriptional activation in vivo". The Journal of Biological Chemistry. 279 (6): 4515–22. doi:10.1074/jbc.M308924200. PMID 14610091.
Balamurugan K, Egli D, Selvaraj A, Zhang B, Georgiev O, Schaffner W (Jul 2004). "Metal-responsive transcription factor (MTF-1) and heavy metal stress response in Drosophila and mammalian cells: a functional comparison". Biological Chemistry. 385 (7): 597–603. doi:10.1515/BC.2004.074. PMID 15318808. S2CID 34611525.
Joshi B, Ordonez-Ercan D, Dasgupta P, Chellappan S (Mar 2005). "Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors". Oncogene. 24 (13): 2204–17. doi:10.1038/sj.onc.1208206. PMID 15735762. S2CID 25970893.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

MTF1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000188786 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028890 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8065932-5] ↑

[entrez-6] 1 2 "Entrez Gene: MTF1 metal-regulatory transcription factor 1".

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