SL88.0338

SL88.0338
Clinical data
Drug class	Serotonin 5-HT1A receptor antagonist
ATC code	None;
Identifiers
	IUPAC name [4-[(5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]piperidin-1-yl]-(3-ethoxyphenyl)methanone;
PubChem CID	10455814;
ChemSpider	8631230;
Chemical and physical data
Formula	C26H34N2O4
Molar mass	438.568 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCOC1=CC=CC(=C1)C(=O)N2CCC(CC2)CN3CCC4=C(C=CC(=C4C3)OC)OC;
	InChI InChI=1S/C26H34N2O4/c1-4-32-21-7-5-6-20(16-21)26(29)28-14-10-19(11-15-28)17-27-13-12-22-23(18-27)25(31-3)9-8-24(22)30-2/h5-9,16,19H,4,10-15,17-18H2,1-3H3; Key:UUKBVYPABSDKFF-UHFFFAOYSA-N;

Pharmaceutical compound

SL88.0338 is a serotonergic drug with a benzoylpiperidine structure, which is used in scientific research. It acts as a potent and selective 5-HT_1A receptor antagonist. It is used for basic research into the action and behavioural effects of 5-HT_1A receptor activation and inactivation.^[1]^[2]^[3]^[4]

References

↑ Griebel G, Rodgers RJ, Perrault G, Sanger DJ (May 1999). "Behavioural profiles in the mouse defence test battery suggest anxiolytic potential of 5-HT(1A) receptor antagonists". Psychopharmacology. 144 (2): 121–130. doi:10.1007/s002130050984. PMID 10394992.
↑ Griebel G, Rodgers RJ, Perrault G, Sanger DJ (July 2000). "The effects of compounds varying in selectivity as 5-HT(1A) receptor antagonists in three rat models of anxiety". Neuropharmacology. 39 (10): 1848–1857. doi:10.1016/s0028-3908(00)00074-5. PMID 10884565.
↑ Depoortere R, Boulay D, Perrault G, Bergis O, Decobert M, Françon D, et al. (November 2003). "SSR181507, a dopamine D2 receptor antagonist and 5-HT1A receptor agonist. II: Behavioral profile predictive of an atypical antipsychotic activity". Neuropsychopharmacology. 28 (11): 1889–1902. doi:10.1038/sj.npp.1300261. PMID 12902993.
↑ Boulay D, Depoortere R, Louis C, Lacave M, Lucas MT, Griebel G (January 2011). "SSR181507, a dopamine D₂ receptor and 5-HT(₁A) receptor ligand: evidence for mixed anxiolytic- and antidepressant-like activities". Pharmacology, Biochemistry, and Behavior. 97 (3): 428–435. doi:10.1016/j.pbb.2010.09.019. PMID 20920519.

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[1] Griebel G, Rodgers RJ, Perrault G, Sanger DJ (May 1999). "Behavioural profiles in the mouse defence test battery suggest anxiolytic potential of 5-HT(1A) receptor antagonists". Psychopharmacology. 144 (2): 121–130. doi:10.1007/s002130050984. PMID 10394992.

[2] Griebel G, Rodgers RJ, Perrault G, Sanger DJ (July 2000). "The effects of compounds varying in selectivity as 5-HT(1A) receptor antagonists in three rat models of anxiety". Neuropharmacology. 39 (10): 1848–1857. doi:10.1016/s0028-3908(00)00074-5. PMID 10884565.

[3] Depoortere R, Boulay D, Perrault G, Bergis O, Decobert M, Françon D, et al. (November 2003). "SSR181507, a dopamine D2 receptor antagonist and 5-HT1A receptor agonist. II: Behavioral profile predictive of an atypical antipsychotic activity". Neuropsychopharmacology. 28 (11): 1889–1902. doi:10.1038/sj.npp.1300261. PMID 12902993.

[4] Boulay D, Depoortere R, Louis C, Lacave M, Lucas MT, Griebel G (January 2011). "SSR181507, a dopamine D₂ receptor and 5-HT(₁A) receptor ligand: evidence for mixed anxiolytic- and antidepressant-like activities". Pharmacology, Biochemistry, and Behavior. 97 (3): 428–435. doi:10.1016/j.pbb.2010.09.019. PMID 20920519.

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v t e Arylpiperazines
Phenylpiperazines	1-Phenylpiperazine (1-PP; PP) 3,4-CFP 2C-B-PP Acaprazine Antrafenine Aripiprazole Batoprazine Bifeprunox BRL-15,572 Ciprofloxacin Dapiprazole DCPP DMPP Diphenylpiperazine Dropropizine EGIS-7625 EGIS-12,233 Elopiprazole Eltoprazine Enpiprazole Ensaculin Etoperidone Flesinoxan Fluanisone Flibanserin Fluprazine Itraconazole Ketoconazole Levodropropizine Lorpiprazole mCPP Mefway MeOPP Mepiprazole Naftopidil Naluzotan Nefazodone Niaprazine Oxypertine Pardoprunox pCPP pFPP Posaconazole S-14,506 S-14,671 S-15,535 SB-258,585 SB-271,046 SB-357,134 SB-399,885 Sonepiprazole TFMPP Tolpiprazole Trazodone Urapidil Vesnarinone Vilazodone Vortioxetine WAY-100,135 WAY-100,635
Benzylpiperazines	2C-B-BZP 3-Methylbenzylpiperazine Befuraline Bifeprunox Buclizine BZP Chlorbenzoxamine DBZP EGIS-7625 Fipexide Imatinib MBZP MDBZP Meclozine Methoxypiperamide NSI-189 Piberaline Piribedil RN-1747 Sunifiram Trimetazidine Vesnarinone
Naphthylpiperazines	1-Naphthylpiperazine (1-NP) 2-Naphthylpiperazine (2-NP) CSP-2503 F-11,461 S-14,506 S-14671
Quinolinylpiperazines	FPPQ 6-Nitroquipazine Isoquipazine Quipazine
Diphenylalkylpiperazines	AD-1211 Almitrine Amperozide BRL-15,572 Buclizine BW373U86 Cetirizine Chlorbenzoxamine Chlorcyclizine Cinnarizine Clocinizine Cyclizine DBL-583 Diphenpipenol Diphenylmethylpiperazine Dotarizine DPI-221 DPI-287 DPI-3290 GBR-12,783 GBR-12,935 GBR-13,069 GBR-13,098 GBR-13,119 Hydroxyzine JJC8-088 Lidoflazine Manidipine Meclozine MT-45 Oxatomide SNC-80 Vanoxerine
Pyrimidinylpiperazines	Buspirone Dasatinib Eptapirone Gepirone Ipsapirone Piribedil Pyrimidinylpiperazine Revospirone Tandospirone Tirilazad Trimazosin Umespirone Zalospirone
Pyridinylpiperazines	Atevirdine Azaperone Delavirdine Mirtazapine ORG-12962 Pyridinylpiperazine
Benzo(iso)thiazolyl piperazines	Lurasidone Perospirone Revospirone Tiospirone Ziprasidone
Tricyclic-linked piperazines	Amoxapine Clopenthixol Clorotepine Clozapine Cyanothepin Doclothepin Docloxythepin Flupentixol Fluphenazine Isofloxythepin Loxapine Meperathiepin Metitepine Octomethothepin Olanzapine Opipramol Oxyclothepin Oxyprothepin Peradithiepin Perathiepin Perazine Perphenazine Pirenzepine Prochlorperazine Thiethylperazine Thiothixene Trifluoperazine Trifluthepin Zuclopenthixol
Others/uncategorized	AP-238 Azimilide Bucinnazine Cinepazet Cinepazic acid Cinepazide CPD-1 Cyclohexylpiperazine Hexocyclium Indinavir JNJ-7777120 Lodenafil MK-212 Mirodenafil PB-28 Ranolazine SA-4503 Sildenafil Tadalafil Vardenafil VCU-1012 VUF-6002 WY-46824 Zipeprol ZINC000443438219

Clinical data

Drug class	Serotonin 5-HT_1A receptor antagonist
ATC code	None
Identifiers
IUPAC name [4-[(5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]piperidin-1-yl]-(3-ethoxyphenyl)methanone
PubChem CID	10455814
ChemSpider	8631230
Chemical and physical data
Formula	C₂₆H₃₄N₂O₄
Molar mass	438.568 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCOC1=CC=CC(=C1)C(=O)N2CCC(CC2)CN3CCC4=C(C=CC(=C4C3)OC)OC
InChI InChI=1S/C26H34N2O4/c1-4-32-21-7-5-6-20(16-21)26(29)28-14-10-19(11-15-28)17-27-13-12-22-23(18-27)25(31-3)9-8-24(22)30-2/h5-9,16,19H,4,10-15,17-18H2,1-3H3 Key:UUKBVYPABSDKFF-UHFFFAOYSA-N

See also

References