• Lilly Singh as Nora Singh, a junior executive at Wax Town Records.
• Bill Barretta as Dr. Teeth, keyboard player and nominal frontman of The Electric Mayhem.
  • Barretta also performs Davis Cactus.
• Leslie Carrara-Rudolph as Penny Waxman, Nora's boss and Dr. Teeth's ex-girlfriend.
• Dave Goelz as Zoot, Mayhem's spaced-out saxophone player.
  • Goelz also performs Jimmy Shoe and Waldorf.
• Eric Jacobson as Animal, a frenzied monster, Floyd's pet monster and the out-of-control drummer for the Mayhem.
• Peter Linz as Lips, Mayhem's incomprehensible trumpet player.
  • Linz also performs Statler.
• David Rudman as Janice, the Mayhem's flower child lead guitarist.
• Matt Vogel as Floyd Pepper, the sarcastic bass player for the Mayhem and Janice's boyfriend.
• Saara Chaudry as Hannah Singh, Nora's younger sister and a successful social media influencer.
• Tahj Mowry as Gary "Moog" Moogwski, an audio engineer and "super fan" of the Electric Mayhem.
• Anders Holm as JJ, a music executive and Nora's ex-boyfriend.

• David Bizzaro and Stephanie D'Abruzzo as Dr. Teeth's controlling dentist parents, Gerald and Tina Teeth.

Additional Muppet performers include Jordan Brownlee, Alice Dinnean, Bradley Freeman, Jr., Donna Kimball, Tim Lagasse, Bruce Lanoil, Drew Massey, Sarah Sarang Oh, Michael Oosterom, Nicolettte Santino, Stoph Scheer, Michelan Sisti, Art Vega and Alex Villa.

The following appeared as themselves : Paula Abdul, Steve Aoki, Karamo Brown, Sofia Carson, Charlamagne Tha God, Tommy Chong, Billy Corgan, deadmau5, Desiigner, Morgan Freeman, Susanna Hoffs, Peter Jackson, Kesha, Tommy Lee, Lil Nas X, Cheech Marin, Ziggy Marley, Ryan Seacrest, Kevin Smith, Chris Stapleton, Danny Trejo, "Weird Al" Yankovic and Zedd.

Archival footage is shown from episodes of The Muppet Show featuring Muppet performers Jim Henson as Teeth, Frank Oz as Animal, Jerry Nelson as Floyd and Richard Hunt as Janice, as well as Elton John as himself.

Following a performance at the 2016 Outside Lands Music and Arts Festival, Muppet performer and writer Bill Barretta developed a pitch for a series based on Dr. Teeth and the Electric Mayhem.^[8] At the same time, Muppet fan Adam F. Goldberg and partner Jeff Yorkes began developing their own project based on the characters; they were interested in a project about the band because they felt their lack of popularity compared to other characters allowed them to "do anything with these guys, because people just know them enough".^[8] While Yorkes initially pitched the idea to Goldberg as a feature film, he suggested developing it as a series instead.^[9] The three eventually began working together on combining their ideas into a single series.^[10]

On February 7, 2022, ABC Signature and The Muppets Studio announced developing a 10-episode series for Disney+ based on The Muppets. Written by Barretta, Goldberg, and Yorkes, The Muppets Mayhem is the first series developed by Goldberg for ABC following his deal with the studio in 2019.^[2] The decision to develop a series based on Dr. Teeth and the Electric Mayhem came from the success of a series of music videos on the Muppets' YouTube channel.^[11] The series was greenlit shortly before its announcement, after finalizing deals with the Muppet performers.^[1] Goldberg and Barretta also executive-produce alongside Michael Bostick, Kris Eber, and The Muppets Studio executives David Lightbody and Leigh Slaughter, while Yorkes is a co-executive-producer.^[1]

On November 21, 2023, it was announced that the series would not be picked up for another season.^[3]

Writers for the series include Julie Bean, Hannah Friedman, Crystal Shaw, Hans Rodionoff, Gabrielle Rodriguez, and Danielle Maransky.^[12] According to executive producer Kris Eber, the filmmakers approached the series like a 5-hour-long feature film.^[12] The series explores the backstory of Electric Mayhem, which has not been depicted in previous projects; the writers worked closely with the Muppet performers to ensure their ideas stayed faithful to the characters.^[9]

The series aimed for a more grounded setting than most Muppet productions, lacking elements such as "talking fruit", with Goldberg saying the show would "[tell] a regular story in the real world with Muppets."^[8] Goldberg said this was because he wanted to portray the band as "like real people, real, breathing entities that can be in the real world."^[9] The number of Muppet elements and characters present in the series was determined according to how natural they were integrated in the story, such as the appearance of Muppet bunnies, which Barretta described as "something that Animal's always had." While appearances from characters such as Kermit the Frog and Miss Piggy were considered, they were discarded early during development to keep the series focused on Electric Mayhem.^[9] Yorkes said the series' comedy would derive from how the band only do whatever they want while Nora tries to lead them in making their album.^[8]

Along with the series' announcement, it was reported that Lilly Singh would portray Nora, a junior executive struggling with the chaos caused by The Electric Mayhem.^[1] Muppet performers Barretta, Dave Goelz, Eric Jacobson, Matt Vogel, David Rudman, and Peter Linz reprised their roles as Electric Mayhem members Dr. Teeth, Zoot, Animal, Floyd Pepper, Janice, and Lips, respectively.^[1] On April 5, 2022, it was confirmed that Tahj Mowry joined the cast.^[13] On June 9, 2022, Saara Chaudry and Anders Holm joined the cast.^[14]

Production for The Muppets Mayhem began April 25, 2022, and ended August 5, 2022.^[15] Craig Kief serves as director of photography.^{[2][16][17][18]} Matt Sohn and Kimmy Gatewood directed episodes.^[18][19] On July 2, 2022, it was reported that an accident took place in which a crew truck crashed into a tree on the edge of a cliff near the Griffith Observatory.^[20]

On May 4, 2023, according to Jordan Williams of Screen Rant, "The anticipation for The Muppets Mayhem clearly extends beyond its core child fanbase, as the series has generated remarkable buzz with over 1.3 million online interactions, becoming the ninth-most hyped May release on Facebook."^[25]

The review aggregator website Rotten Tomatoes reported an approval rating of 86% based on 28 reviews with an average rating of 7.2/10. The site's critics consensus reads: "The Muppets Mayhem might be too slight to find the Rainbow Connection, but its ragtag band of plucky puppets and plethora of showbiz gags make for a solid addition to the franchise.^[26] On Metacritic, the series has a weighted average score of 70 out of 100, based on 11 critics, indicating "generally favorable reviews".^[27]