• Josh Peck as Scott Turner Jr., a buttoned-down and ambitious U.S. Marshal, the son of the late Det. Scott Turner Sr., who ends up inheriting an unruly dog.^[2][8]
• Arnie, Hammer, Obi, Cyd, and Mya as Hooch, the role is played by five different dogs of the same breed.^[9]
• Carra Patterson as Jessica Baxter, Scott's partner, whose personality is a "sharp contrast to his spit-and-polish ways", and who has a brave and quick-thinking personality while working, through whose sense of humor often leads her into trouble.^[7] As of "In The Line of Fur", she's placed on desk duty due to her pregnancy.
• Lyndsy Fonseca as Laura Turner, Scott's sister and a veterinary assistant, who brings Hooch to Scott while coming to terms with their father's death, as she ropes Scott into investigating it.^[7]
• Vanessa Lengies as Erica Mouniere, a dog lover and trainer at the U.S. Marshal K-9 facility with a crush on Turner, who agrees to train Hooch.^[10]
• Brandon Jay McLaren as Xavier "X" Wilson, a marine-turned-US Marshal, who develops a soft spot for Hooch in spite of being a cat lover. One of the office's most experienced members, he is described as "cool and enigmatic and a bit quirky".^[11]
• Jeremy Maguire as Matthew Garland, Laura's son and Scott's nephew. He is a dog lover, and becomes thrilled when Scott inherits Hooch.^[11]
• Anthony Ruivivar as James Mendez, a US Marshal Chief and Scott's boss, who respects Scott but initially is uncomfortable with Hooch, only to give him authorization to receive K-9 training after he helps solve a case.^[11]

• Sheila Kelley as Dr. Emily Turner, Scott's mother and veterinarian. She was previously portrayed by Mare Winningham in the original film and Wendee Pratt in the 1990 pilot.^[12]
• Reginald VelJohnson as David Sutton, a former police detective partner of the late Scott Turner Sr. and now mayor of Cypress Beach. VelJohnson is the only actor from the original film to appear in the series.^[13]

• Matt Hamilton as Trent Havelock, Senior Deputy Marshal to Scott Turner and doesn't much like dogs. He gets all the fame, all the glory, and all the great cases — everything Scott thinks he wants.^[14]
• Becca Tobin as Brooke Mailer, Scott's girlfriend and a prosecutor who downplays her status as part of a wealthy family of powerful lawyers. She is described as representing "everything Scott thinks he wants out of life".^[11]
• Paul Campbell as Grady Garland, Laura Turner's ex-husband and Matthew's father. He's a well-meaning small-town cop who peaked in high school and at this point probably has more in common with his 8-year-old than his ex.^[14]
• Cristina Rosato as Olivia, Xavier Wilson's fiancée and an Oakland cop from the Midwest. She's warm, earnest and enthusiastic — seemingly the complete opposite of her enigmatic soon-to-be husband.^[14]

In 1990, Touchstone Television developed a TV pilot based on the Touchstone Pictures film Turner & Hooch, with Thomas F. Wilson starring as Scott Turner and Beasley the Dog reprising his role from the film as Hooch.^[6] The pilot was not green-lit for a series order, and was ultimately aired as part of The Magical World of Disney in July 1990.^[6] A television series reboot developed by Matt Nix was announced to be in development for the Disney+ streaming service in December 2019,^[6] officially receiving a 12-episode order in February 2020; Josh Peck was cast as Scott Turner.^[8] That same month, Lyndsy Fonseca and Carra Patterson joined the cast, while Josh Levy was revealed to be co-executive-producing the series.^[7] On March 6, Vanessa Lengies joined the cast.^[10] In January 2021, it announced that McG would direct the pilot and also serve as executive producer.^[16] On December 2, 2021, Disney+ canceled the series after one season.^[4]

On September 22, 2020, the day filming began, Anthony Ruivivar, Brandon Jay McLaren, and Jeremy Maguire joined the cast in lead roles, while Becca Tobin joined in the recurring role.^[11] In January 2021, Paul Campbell was cast in the recurring role.^[14]

Filming for Turner & Hooch was originally scheduled to begin on April 27, 2020, taking place in Vancouver, British Columbia, Canada.^[17] Fonseca filmed the series concurrently with Fox's 9-1-1: Lone Star.^[7] Filming was delayed and began on September 22, 2020,^[18] and was scheduled to conclude on April 19, 2021.^[18]

On Rotten Tomatoes, the series holds an approval rating of 57% based on 21 critic reviews, with an average rating of 5.8/10. The website's critical consensus reads, "Likeable, but slight, Turner & Hooch features a mighty fine pooch, but those looking for more narrative meat may want to try a different bone."^[22] On Metacritic, the film has a weighted average score of 49 out of 100, based on 7 critics, indicating "mixed or average reviews".^[23]

Matt Fowler of IGN gave the show 6 out of 10 and stated, "Nothing feels dumbed down or muted, though the dog dilemma involving Hooch being thrust upon an unwilling owner feels like a questionable situation now instead of a light-hearted romp."^[24] Lucy Mangan of The Guardian rated the series 3 out of 5 stars, writing, "Josh Peck and his law-enforcing hound do their best to follow in the pawsteps of the Tom Hanks original, but this remake is all bark and no bite."^[25] Ashley Moulton of Common Sense Media gave the show 3 out of 5 and an '11+' age rating, stating, "Dog-loving teens may enjoy this show, which is relatively tame in most aspects besides the violence, but many will roll their eyes at the cheesy dialogue and storylines."^[26]

Joel Keller of Decider gave the series a mixed review and wrote: "We’re recommending Turner & Hooch mostly for the dog. He’s not quite as slobbery as the original Hooch, but he’s definitely slobbery enough to contrast with the fastidious Scott Turner. Without Hooch, the show is mostly a generic basic-cable mystery series; if it can’t develop better relationships between its characters, the dog will still be the only thing keeping us watching."^[27] Daniel Fienberg of The Hollywood Reporter gave the show a negative review and stated, "I'm not even complaining when I call Turner & Hooch a forgettable, one-joke series. It's hard to know what else it could have been."^[12] Brian Lowry of CNN gave the show a negative review and stated, "Even if Hooch sits at attention like a good dog, after a few episodes of Turner & Hooch, it's hard to share that patience or loyalty."^[28] Alan Sepinwall of Rolling Stone gave the show 2.5 out of 5 and stated, "It leans much too hard into the corny aesthetic of those kinds of lighthearted dramas, creating something too silly and childish for most adults, yet likely too old-fashioned for their own children."^[29]

Jon Kralt was nominated for a 2022 Leo Award in the category Best Stunt Performance in a Dramatic Series for work in this series.^[30]