diff --git a/Misc/NEWS.d/next/Build/2021-11-01-08-43-12.bpo-45598.cAHNki.rst b/Misc/NEWS.d/next/Build/2021-11-01-08-43-12.bpo-45598.cAHNki.rst
@@ -0,0 +1,3 @@
diff --git a/Modules/_ctypes/callbacks.c b/Modules/_ctypes/callbacks.c
@@ -417,19 +417,18 @@ CThunkObject *_ctypes_alloc_callback(PyObject *callable,
                     "ffi_prep_cif failed with %d", result);
        goto error;
    }
-#if HAVE_FFI_PREP_CLOSURE_LOC
#   if USING_APPLE_OS_LIBFFI
#      define HAVE_FFI_PREP_CLOSURE_LOC_RUNTIME __builtin_available(macos 10.15, ios 13, watchos 6, tvos 13, *)
#   else
#      define HAVE_FFI_PREP_CLOSURE_LOC_RUNTIME 1
#   endif
    if (HAVE_FFI_PREP_CLOSURE_LOC_RUNTIME) {
        result = ffi_prep_closure_loc(p->pcl_write, &p->cif, closure_fcn,
                                    p,
                                    p->pcl_exec);
-    } else
-#endif
-    {
#if USING_APPLE_OS_LIBFFI && defined(__arm64__)
        PyErr_Format(PyExc_NotImplementedError, "ffi_prep_closure_loc() is missing");
        goto error;

diff --git a/Modules/_ctypes/callproc.c b/Modules/_ctypes/callproc.c
@@ -828,10 +828,10 @@ static int _call_function_pointer(int flags,

#   if USING_APPLE_OS_LIBFFI
#      define HAVE_FFI_PREP_CIF_VAR_RUNTIME __builtin_available(macos 10.15, ios 13, watchos 6, tvos 13, *)
-#   elif HAVE_FFI_PREP_CIF_VAR
-#      define HAVE_FFI_PREP_CIF_VAR_RUNTIME true
-#   else
#      define HAVE_FFI_PREP_CIF_VAR_RUNTIME false
#   endif

    /* Even on Apple-arm64 the calling convention for variadic functions coincides
@@ -843,16 +843,12 @@ static int _call_function_pointer(int flags,
    (void) is_variadic;

#if defined(__APPLE__) && defined(__arm64__)
-    if (is_variadic) {
-        if (HAVE_FFI_PREP_CIF_VAR_RUNTIME) {
-        } else {
-            PyErr_SetString(PyExc_NotImplementedError, "ffi_prep_cif_var() is missing");
-            return -1;
-        }
    }
#endif

-#if HAVE_FFI_PREP_CIF_VAR
    if (is_variadic) {
        if (HAVE_FFI_PREP_CIF_VAR_RUNTIME) {
            if (FFI_OK != ffi_prep_cif_var(&cif,
@@ -876,10 +872,7 @@ static int _call_function_pointer(int flags,
                return -1;
            }
        }
-    } else
-#endif
-
-    {
        if (FFI_OK != ffi_prep_cif(&cif,
                                   cc,
                                   argcount,

diff --git a/Modules/_ctypes/malloc_closure.c b/Modules/_ctypes/malloc_closure.c
@@ -91,15 +91,13 @@ static void more_core(void)
/* put the item back into the free list */
void Py_ffi_closure_free(void *p)
{
-#if HAVE_FFI_CLOSURE_ALLOC
#if USING_APPLE_OS_LIBFFI
    if (__builtin_available(macos 10.15, ios 13, watchos 6, tvos 13, *)) {
#endif
        ffi_closure_free(p);
        return;
#if USING_APPLE_OS_LIBFFI
    }
-#endif
#endif
    ITEM *item = (ITEM *)p;
    item->next = free_list;
@@ -109,14 +107,12 @@ void Py_ffi_closure_free(void *p)
/* return one item from the free list, allocating more if needed */
void *Py_ffi_closure_alloc(size_t size, void** codeloc)
{
-#if HAVE_FFI_CLOSURE_ALLOC
#if USING_APPLE_OS_LIBFFI
    if (__builtin_available(macos 10.15, ios 13, watchos 6, tvos 13, *)) {
#endif
        return ffi_closure_alloc(size, codeloc);
#if USING_APPLE_OS_LIBFFI
    }
-#endif
#endif
    ITEM *item;
    if (!free_list)