Message 173373 - Python tracker
I can reproduce this on Linux (3.3+ only):
$ name=$(printf "\xff")
$ echo "print('Hello, world')" >$name
$ ./python $name
python: failed to set __main__.__loader__
The issue is in PyRun_SimpleFileExFlags() function, which gets raw char * as the file name (the documentation says about the filesystem encoding (sys.getfilesystemencoding())), but then this name decoded from UTF-8 in set_main_loader().