I could change STORE_ANNOTATION opcode so that it will recreate __annotations__ if __name__ == '__main__'.
Or do you now think that it should re-create it always? I still think that always re-creating __annotations__ if they don't exist seems like silencing a possible error. As I mentioned in previous discussion, I think we should allow people to explicitly del __annotations__ (for example if someone wants to make a class with annotations that are "invisible" to runtime tools) and warn them if later they use annotations.