bpo-46329: Avoid `PUSH_NULL` when followed by `LOAD_GLOBAL` by markshannon · Pull Request #31933 · python/cpython
Uses the low bit of LOAD_GLOBAL's oparg to indicate whether it should push a NULL first.
len(alist)
now compiles to
LOAD_GLOBAL 1 (NULL + len)
LOAD_FAST 0 (alist)
PRECALL 1
CALL 1
This reduces the total number of VM instructions executed by ~2%.
The benchmark results show an unlikely 3% speedup, probably just one of those random build variations.